ผู้วิจัย/Authors: Kanchana Hattasin

ชื่อเรื่อง/Title: Case Report : Clozapine-induced agranulocytosis. Case Report : Clozapine-induced agranulocytosis.

แหล่งที่มา/Source: Bulletin of Suanprung. Vol. 23, No. 3, September-December 2007, page 34-35.

รายละเอียด / Details:

Clozapine is the atypical antipsychotic used in patients who did not respond to other antipsychotics. Because of a serious adverse drug reaction, agranulocytosis may cause patient death from infection. It is needed to regularly monitor white blood cells count. A Thai patient, aged 45 year-old man, who was diagnosed as undifferentiated schizophrenia (F 20.3) was treated with clozapine and he developed agranulocytosis within 1 month. The patient was referred to the Maharaj Nakhon Chiang Mai Hospital because of his serious infection and was eventually discharged with improvement. Within 3 months, the patient had a relapse and was referred by a local hospital to Suan Prung Psychiatric Hospital. At this place, a doctor started clozapine again after 1 month of failed treatment with others drug choices. The CBC monitoring was done weekly. He was improved within 1 month later and was ready to be discharged. While waiting for his relatives to pick him up home, he was moved to the remote Thanu Ward, without CBC monitoring for three weeks. He developed agranulocytosis again and after that he was diagnosed as sepsis. He was referred to Nakornping Hospital. When he was recover, the doctor started to treat him with perphenazine and discharged him with improvement. Clozapine is the atypical antipsychotic used in patients who did not respond to other antipsychotics. Because of a serious adverse drug reaction, agranulocytosis may cause patient death from infection. It is needed to regularly monitor white blood cells count. A Thai patient, aged 45 year-old man, who was diagnosed as undifferentiated schizophrenia (F 20.3) was treated with clozapine and he developed agranulocytosis within 1 month. The patient was referred to the Maharaj Nakhon Chiang Mai Hospital because of his serious infection and was eventually discharged with improvement. Within 3 months, the patient had a relapse and was referred by a local hospital to Suan Prung Psychiatric Hospital. At this place, a doctor started clozapine again after 1 month of failed treatment with others drug choices. The CBC monitoring was done weekly. He was improved within 1 month later and was ready to be discharged. While waiting for his relatives to pick him up home, he was moved to the remote Thanu Ward, without CBC monitoring for three weeks. He developed agranulocytosis again and after that he was diagnosed as sepsis. He was referred to Nakornping Hospital. When he was recover, the doctor started to treat him with perphenazine and discharged him with improvement.

Keywords: clozapine, agranulocytosis, adverse drug reaction (adr) clozapine, agranulocytosis, adverse drug reaction (adr)

ปีที่เผยแพร่/Year: 2008

Address: เภสัชกร โรงพยาบาลสวนปรุง

Code: 201000072

ISSN/ISBN: -

Country of publication: Thailand

Language: English

Category: Abstract

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