ผู้วิจัย/Authors: Sudsabuy Chulakadabba

ชื่อเรื่อง/Title: Clozapine Treatment in 12 Chronic-Rasistant Schizoprenic Patients

แหล่งที่มา/Source: Siriraj Hospital Gazette, Vol. 51, No 9, January 1998, Page 86-90.

รายละเอียด / Details:

Schizophrenia is a chronic disease and has been treated by typical antipsychotic drugs which act on dopamine receptor antagonists. The result of treatment is usually 1/3 response and 2/3 partial response or non-response. Clozapine is a typical anti-psychotic durg which act on serotonin and dopamine receptor antagonists. Between 40 and 80 percent of chronic resistant schizophrenia cases respond to clozapine. The effect was studied of clozapine on 12 chronic resistant schizophrenia cases, five males 41.7 percent and seven females 58.3 percent; with a mean age of 36.6 years; verage duration of illness 15.8 years; average dose 100mg/day; duration of follow-up 231.6 days. Ten cases 83.3 percent showed improvement, ehile two cases showed mild or no improvement.

Keywords: clozapine, antipsychotic drug, schizophrenia, psychiatry

ปีที่เผยแพร่/Year: 1998

Address: Faculty of Medicine Siriraj Hospital, Mahidol University

Code: 00004158

ISSN/ISBN: 0125-152X

Country of publication: Thailand.

Language: English.

Category: Abstract Journal.

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