ผู้วิจัย/Authors: Chamlong Disayavanish, Primprao Disayavanish

ชื่อเรื่อง/Title: Update on Depression

แหล่งที่มา/Source: Journal of the Psychiatric Association of Thailand, Vol.48, No. 3, July-September 2003, Page 185-199.

รายละเอียด / Details:

The progress outlined in this review provides new approaches and hypothese for the field of depression. Several studies have identified neural circuity of limbic brain structures that is involved in depression. Stress and glucocorticoids can cause atrophy of the apical dendrites of CA3 pyramidal neurons and suppress neurogenesis of dentate gyrus granule neurons in the hippocampus resulting in the decrease of its volume. These stress-induced effects were prevented and reversed by treatment with tianeptine which belongs to selective serotonin reuptake enhancer (SSRE) Stress and glucocorticoids also influence a number of signaling pathways that are related to the alteration of neuroplasticity of hippocampal neurons. Research in this area has focused on three effects: 1) glucocorticoid-induced reduction in glucose utilization, 2) increased glutamate excitotoxicity, and 3) decreased expression of brain-derived neurotrophic factor (BDNF) The discovery that antidepressant treatment causes upregulation of the camp response element binding (CREB) protein cascade and induction of the BDNF system provides the sigificant development of novel antidepressant agents. There is new knowledge that synaptic connections can be permanently altered and strengthened through the regulation of gene expression connected with learning from the environment. Since the brain itself is a plastic and dynamic structure, it is postulated that psychotherapy as a form of learning may produce similar alteration.

Keywords: depression, neural circuity, signaling pathway, neuroplasticity, novel antidepressants, psychotherapy, depress, psychiatry, SSRE, antidepressant, review, new approach

ปีที่เผยแพร่/Year: 2003

Address: Department of Psychiatry, Faculty of Medicine, Chiang Mai University

Code: 20040000275

ISSN/ISBN: 0125-6985

Country of publication: Thailand

Language: English.

Category: review articles

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