ผู้วิจัย/Authors: Veeravan Lekskulchai

ชื่อเรื่อง/Title: Isomeric Separation of Methamphetamine by HPLC Chiral Column

แหล่งที่มา/Source: Journal of the Medical Association of Thailand, Vol. 84, No. 11, November 2001, Page 1604-1613.

รายละเอียด / Details:

Methamphetamine and its active metabolite, amphetamine, are optically active compounds which, based upon synthetic routes,can be found in two forms; pure d-form and racemic mixture. Analysis of their isomers can help to identify which precursor is currently spreading widely in a given region. Since there are many drugs that can be metabolized to amphetamine/methamphetamine, isomeric separation can be a useful tool for evaluation of these drugs, as well. indirect method by using N-trifluoroacetyl-1 prolyl chloride (1-TPC) was found to have limite accuracy due to the contribution effect. in this presentation a direct method using HPLC Chirex chiral columan 3022 was studied. Although the method gave no base-line separation of two different isomer peaks, it gave good sensitivity, reliability, and linearity. No contribution effect was found in the method presented. It also gave excellent correlation with the 1-TPC method.

Keywords: methamohetamine, amphetamine, drugs, drug addict, abuse, substance dependence

ปีที่เผยแพร่/Year: 2001

Address: Department of Pathology Faculty of Medicine Srinakharinwirot University.

Code: 00000000100

ISSN/ISBN: 0125-2208

Country of publication: Thailand

Language: English.

Category: Abstract Journal.

Download: -