ฐานข้อมูลวิจัยด้านสุขภาพจิตและจิตเวช

ผู้วิจัย/Authors: Nahathai Wongpakaran.

ชื่อเรื่อง/Title: Selective serotonin reuptake inhibitor (SSRI) use associates with apathy among depressed elderly: a case control study.

แหล่งที่มา/Source: การประชุมวิชาการประจำปี ราชวิทยาลัยจิตแพทย์แห่งประเทศไทย, หน้า 32.

รายละเอียด / Details:

Objective : To investigate the possibility of the association between SSRI use and the occurrence of apathy among elderly depressed patients. Methods : Baycrest Centre for Geriatric Care's Day Hospital Database of elderly depressed patients who received antidepressants was divided into 2 groups depending on antidepressant use at discharge: SSRI user group-SUG, and non-SSRI user group-NSUG. Apathy scales developed by the authors were selected from the Geriatric Depression Scale (GDS) and the Hamilton Rating Scale for Depression (HAMD), and were titled as GDS-apathy subscale (GAS) and HAMD-apathy subscal (HAS). An analysis of variances, a Chi-square test and odds ratio with 95% confidence interval reported. Results : Among 384 patients (160 SUG and 224 NSUG), mean GDS and HAMD at discharge were 12.46 and 10.61 in SUG, and were 11.37 and 9.30 in NSUG, respectively, Using GAS for apathy assessment, 83.7% of patients in SUG and 73.4% in NSUG stayed apathetic at discharge. As evaluated by HAS, 44.2% of patients in SUG and 36.5% in NSUG stayed apathetic. SSRI use was not a predictor of apathy at admission, while it was at discharge, p=0.029. The SUG showed more patients with apathy than that found in NSUG with an adjusted OR of 1.90 (1.14-3.17). Conclusion : Apathy appeared to be greater in patients who had history of SSRI use than that found in patients who did not.

Keywords: SSRI, drug, antidepressant, selective serotonin reuptake inhibitor, psychiatry, depression, depress

ปีที่เผยแพร่/Year: 2004

Address: Baycrest Centre for Geriatric Care

Code: 20050000606

ISSN/ISBN:

Country of publication: Thailand.

Language: English.

Category: Paper ที่ได้รับคัดเลือกนำเสนอในที่ประชุมวิชาการประจำปี ราชวิทยาลัยจิตแพทย์แห่งประเทศไทย ปี 2548

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