ผู้วิจัย/Authors: Lalita Nantpong.

ชื่อเรื่อง/Title: Efficacy and side effect of topiramate in treatment of bipolar disorder patients.

แหล่งที่มา/Source: Journal of the Psychiatric Association of Thailand. Vol.51, No.3, July-September 2006, Page 298-303.

รายละเอียด / Details:

Objective: To study the efficacy and side effect of Topiramate in treatment of Bipolar disorder patients. Method: The study was conducted in bipolar patients at King Chulalongkorn Memorial Hospital during August 2000 to December 2002. The dose of Topiramante was 25-500 mg/per day. The Clinical Global Impression (CGI) was used to determine the efficacy of treatment. The adverse effects were present in detail. Result: There were forty cases of Bipolar disorder patients. The mean age was 38.5 year. There were thirty-one female and nine male. The average duration of symptoms were 10.6 years. The patients received 142.9 mg per day average of Topiramate for 5 months. The study demonstrated the efficacy of Topiramate which statistically improved the CGI scores. Most of the commonly reported adverse effects of Topiramate were mild to moderate such as headache depressed mood nausea/vomiting numbness and cognitive dullness. The patients had average 2.7 kg weight loss. The concomitant medications were Lithium anticonvulsant low dose narcoleptic and antidepressants. Conclusion: Topiramate had the efficacy to treatment bipolar disorder. The most common adverse effects was headache which was tolerable. The favorable side effect was the body weight loss.

Keywords: topiramate, bipolar disorder, efficacy, side effect, weight loss, treatment, antidepressant, psychiatry

ปีที่เผยแพร่/Year: 2006

Address: Department of Psychiatry, Faculty of Medicine, Chulalongkorn University.

Code: 200700033

ISSN/ISBN: 0125-6985

Country of publication: Thailand.

Language: English

Category: Abstract Journal.

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