ฐานข้อมูลวิจัยด้านสุขภาพจิตและจิตเวช

ผู้วิจัย/Authors: Lanchasak Akkayagorn, Sookjaroen Tangwongchai, Paungsoy Worakul

ชื่อเรื่อง/Title: Cognitive Profiles Hormonal Replacement Therapy and Related Factors in Thai Menopausal Thailand.

แหล่งที่มา/Source: Mental Health in the City. No.6, 2007.1-3 August 2007 ณ. โรงแรมปรินซ์พาเลซ กรุงเทพมหานคร Page 36.

รายละเอียด / Details:

Objactive. The purposes of this descriptive study was to examine the characteristics of cognitive functions hormonal replacement therapy and related factors among menopausal women at menopausal clinic at King Chulalongkorn memorial hospital. Methods. 210 subjects were systematically randomized in this crossectional descriptive study. The instruments composed of self-reported questionnaires assessment for demographic data and related factors center for epidemiologic studies depression symptomatology scale (CES-D). Thai mini-mental state examination (TMSE) and neuropsychological battery in Thai version including digit span and visual memory span test verbal paired association l test and similarities test were used to evaluate for attention & concentration verbal memory & learning and concept formation respectively. The data were statistically analyzed by using SPSS for windows version 12.0 for descripive and inferrential statistics as weell as multiple regression analysis. Results. The results revealed that 99%of subjects had normal condition of TMSE score at least 24 with mean of 28.54 1.64 points 12.9% of subjects had TMSE score 24-25 for possible mild cognitive impairment according to 2 SD cut-point score. Others cognitive test scores were found to have normal distribution digit span test (Mean=14.47+2.81) visual memory span test (Mean=13.31+2.85) verbal paired associate 1 test (Mean=4.58+1.27) and similarities test. (Mean=14.59+4.36).59.5% of the sample were on hormonal replacement therapy (HRT) Univariate analyses were performed and shown that subjects with TMSE score more than 26 were related with history of aerobic exercise Subjects with TMSE score of possible cognitive impairment had lower similarities test scores Supplementary food using and HRT were not related with impairment of cognitive functions. Other factors including age educational level monthly income and occupation were related with most cognitive score. Multiple regression analyses revealed that low Educational level can predict low TMSE score Low educational level and monthly income could predict low digit span test score Low monthly income older age low educational level could predict low visual memory span test score Low verbal paired associate l test score could be predicted by low monthly income And low Similarities test score could be predicted by educational level below diploma degree. Conclusion The cognitive functions of most studied subjects were normal Factors that could predict the cognitive function score were age and educational level Subjects that had no aerobic exercise and low Concept formation score were related with low TMSE score HRT was not related with cognitive deficits in this study.

Keywords: hormonal replacement therapy, menopause, CES-D, TMSE test, cognitive test, depression study, mental health, mental state, depress

ปีที่เผยแพร่/Year: 2007

Address: Ministry of Public Health Department of Mental Health Nakhonphanom Mental Hospital Nakhonphanom Thailand Department of Psychiatry Faculty of Medicine Chulalongkorn University Bangkok Thailand

Code: 200700072

ISSN/ISBN: 2859-497-X

Country of publication: Thailand

Language: English

Category: abstract

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