ฐานข้อมูลวิจัยด้านสุขภาพจิตและจิตเวช

ผู้วิจัย/Authors: Thoranin Kongsuk

ชื่อเรื่อง/Title: Moclobemide and Alprazilam in the Treatment of Panic Disorder: A Double-Blind Study.

แหล่งที่มา/Source: Journal of the Psychiatric Association of Thailand. Vol. 47, No. 4, October-December 2002, Page 247-253.

รายละเอียด / Details:

Objective: The purpose of theis research was to evaluate the efficacy and tolerability of moclobemide and alprazolam in the treatment of panic disorder in Thai patients. Methods: A randomized double-blind controlled trial was conducted. One hundred and eighty-six patients with panic disorder were enrolled for an eight-week treatment period. Ninety-three patients were randomly allocated to the moclobemide grpup, and ninety-three patients to the alprazolam group. The total number of panic attacks occurring each week after intervention was recorded. The attacks were indentified by DSM-IV criteria. The efficacy of moclobemide and alprazolam in reducing panic attacks was analyzed by using poisson regression. Results: The incidence of panic attacks decreased during the first week in both treatment groups, and the decrease was maintained until the end of the study. At week 1, alprazolam showed greater efficacy in reducing panic attacks than moclobemide, with the difference of incidence rate being 0.96 0.96 95% CI=0.36-1.55 but at week 3, moclobemide turned out to be more effective than alprazolam. The differences in incidence rates from week 4 through week 8 were -0.42 95% CI=(-0.62)- (-0.24)-0.27 95% CI= (-0.42)- (-0.13) -0.44 95% CI= (-0.61)- (-0.27) -0.17 95% CI= (-0.29) - (-0.05) -0.22 95% CI= (-0.34) -(0.11) , respectively. As regards adverse events, moclobemide caused insomnia and dry mouth more often than alprazolam, while alprazolam caused sommolence more frequently than moclobemide. Conclusions: Moclobemide and alprazolam appear efficacious in treating panic disorder. The reports of advers events caused by both drugs generally indicated mild to moderate severity. Patients seemed to tolerate both medications well as there was no patiens with drawing from the teatment due to adverse events of these drugs

Keywords: moclobemide, alprazolam, panic disorder, efficacy, tolerability, drug, pharmarcology, panic attack, psychiatry

ปีที่เผยแพร่/Year: 2002

Address: Loei Psychiatric Hospital

Code: 000000006

ISSN/ISBN: 0125-6985

Country of publication: Thailand.

Language: English.

Category: Abstract Journal.

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