ผู้วิจัย/Authors: Manit Srisurapanont, M.D. Narong Maneeton, M.D.

ชื่อเรื่อง/Title: Efficacy and Acceptability of Atypical Antipsychotics

แหล่งที่มา/Source: Journal of The Psychiatric Association of Thailand, Vol. 44 No.2 April-June 1999, P 147-155.

รายละเอียด / Details:

Objective To compare the differences of efficacy and acceptability between atypical and classical antipsychotics, we conducted a meta-analysis of published, randomized-controlled trials carried out in adult patients with schizophrenia. Methods By using MEDLINE, we comprehensively searched papers relevant to randomized-controlled trials of olanzapine, risperidone, and quetiapine. In each study, the response and dropout rates of patients treated with an atypical antipsychotic and those treated with a classical antipsychotic were extracted on an intention-to-treat basis. Results Fifteen studies included in this meta-analysis were 10 risperidone, 3 olanzapine, and 2 quetiapine trials. In comparison to classical antipsychotics, the response-rate effect size (95% CI) and the drop-out effect size (95% CI) of atypical antipsychotics were 1.38 (1.05 to 1.82) and 0.70 (0.53 to 0.92), respectively. Conclusions Atypical antipsychotics are more effective and more acceptable than classical antipsychotics in treating schizophrenic patients. However, due to the high cost of drugs, physicians should take patients’ circumstances and wishes into account in prescribing atypical antipsychotics.

Keywords: olanzapine, quetiapine, risperidone, randomized-controlled trial, meta-analysis, antipsychotic agents, schizophrenia, psychiatry, atypical antipsychotic

ปีที่เผยแพร่/Year: 1999

Address: Department of Psychiatry, Chiang Mai University Faculty of Medicine, Amphur Muang, Chiang Mai, 50200 Thailand.

Code: 00000127

ISSN/ISBN: 0125-6985

Country of publication: Thailand.

Language: English.

Category: Abstract Journal.

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