ผู้วิจัย/Authors: Kasem Tantiphlachiva M.D.

ชื่อเรื่อง/Title: Neuroleptic Malignant Syndrome : A Five-Year Review

แหล่งที่มา/Source: Journal of The Psychiatric Association of Thailand, Vol. 44 No.3 July-September 1999, P 189-200.

รายละเอียด / Details:

Neuroleptic malignant syndrome (NMS) is the most serious and potentially fatal complication of neuroleptic pharmacotherapy. This is a retrospective study of cases at Somdet Chaopraya Hospital from 1994 to 1998. Twelve cases were diagnosed as developing NMS during the five-year period, revealing the incidence of 0.04%, which would have been higher if cases without laboratory investigations were included. Half of the patients were diagnosed as schizophrenia. Fever, sweating, muscle rigidity, leucocytosis, and increased creatine phosphokinase were found in every case. Predisposing factors were agitation, dehydration, exhaustion, use of depot neuroleptics and frequent intramuscular injections. The mortality rate was 16.67%. Suggestions are made for clinicians, emphasizing more awareness leading to early recognition of the condition and to ensure prompt treatment, thereby reducing mortality and morbidity.

Keywords: neuroleptic malignant syndrome, incidence, predisposing factors, psychiatry, schizophrenia

ปีที่เผยแพร่/Year: 1999

Address: Somdet Chaopraya Hospital, Klongsan, Bangkok 10600

Code: 00000128

ISSN/ISBN: 0125-6985

Country of publication: Thailand.

Language: English.

Category: Abstract Journal.

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