ผู้วิจัย/Authors: Pattanop Tansupasiri

ชื่อเรื่อง/Title: The prevalence of metabolic syndrome in patients with schizophrenia at psychiatric outpatient clinic, Srinagarind Hospital.

แหล่งที่มา/Source: Journal of the Psychiatric Association of Thailand,Vol. 53, No. 1, January-March 2008, Page 98.

รายละเอียด / Details:

Objective: To determine the prevalence of metabolic syndrome in patients with schizophrenia and to distinguish the difference between the prevalence of patients receiving conventional antipsychotic drugs and patients receiving atypical antipsychotic drugs. Other associating factors with metabolic syndrome were also concluded. Materials and Methods: A Cross-sectional descriptive study was conducted by pooling a sample of 156 patients with schizophrenia (bass on DSM-IV-TR criteria) at psychiatric outpatient clinic, Srinagarind Hospital from December 2006 to February 2008. Height, body weight, waist measurement, blood pressure were measured and BMI was calculated. Data on age, sex, family history of hypertension, DM,dyslipidemia, and abdominal obesity, exercise behavior, history of sweet and high fat diet in the previous year, treatment history, comorbidity, type and duration of receiving antipsychotic drugs, type of schizophrenia according to outpatient records, and blood sugar, trigyceride, cholesterol, HDL after 8 hours of fasting were recorded. Metabolic syndrome was diagnosed by using IDF criteria. Mean, SD, and percent were used in analyzing demographic data. Factors associating with metabolic syndrome were analyzed by using univariate analysis to define OR and 95% CI and Chi Square to define p-value. Stepwise multiple logistic regression was used to find the most associating factor with metabolic syndrome Results: The prevalence of metabolic syndrome was 15.4% (defined by IDF criteria) and 20.5% (defined by Updated ATP III with significance difference (p=0.008). Both criteria had a significant correlation (Kappa=0.83, 95% CI=0.71-0.94, p=0.000). The prevalence of metabolic syndrome in patients receiving conventional antipsychotic drugs was 9.4% and 20% in those receiving atypical antipsychotic drugs. Associating factors with metabolic syndrome were receiving atypical antipsychotic drugs (OR=21., 95% CI= 0.5-8.5, p = 0.27), a family hostory of hypertension (OR=2.0, 95% CI= 0.8-5.1, p=0.13), female (OR=1.5, 95% CI=0.6-3.7, p= 0.33), and no diet control (OR=1.1, 95% CI=0.5-2.9, p=0.78) but without statistic significance. In stepwise multiple logistic regression analysis, metabolic syndrome had a correlation with receiving atypical antipsychotic drugs (OR=3.3, 95% CI= 1.1-10.1, p=0.04) and a family history of hypertension (OR=3.2. 95% CI=1.1-9.8, p=0.04) with statistic significance. Conclusion: The prevalence of metabolic syndrome in Thai patients with schizophrenia was 15.4%. Statistic significance of factors associated with metabolic syndrome was those who receiving atypical antipsychotic drugs and had family history of hypertension.

Keywords: metabolic syndrome, schizophrenia, prevalence, antipsychotic drugs, psychiatry

ปีที่เผยแพร่/Year: 2008

Address: Department of Psychiatry, Faculty of Medicine, Khon Kaen University

Code: 20080076

ISSN/ISBN: 0125-6985

Country of publication: Thailand

Language: English

Category: Abstract

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