ผู้วิจัย/Authors: Thoranin Kongsuk

ชื่อเรื่อง/Title: Association between stressful life events and the onset of major depressive disorder episode in patients from five university hospital in Thailand 2006.

แหล่งที่มา/Source: Journal of the Psychiatric Association of Thailand,Vol. 53, No. 1, January-March 2008, Page 61.

รายละเอียด / Details:

Objective: To study association between stressful life events and the onset of major depressive disorder in patients from five university hospital in Thailand, 2006. Methods: This research was a hospital-based, and case-control study conducted with 339 patients aged 18-59 who received services from five university hospital in each of the four regions in Thailand. The cases consist of new patients diagnosed with major depressive disorder by psychiatrists based on DSM-IV, old patients diagnosed between January 1 and November 31st, 2006. Moreover, these patients had to agree to be interviewed. Patients diagnosed with other kinds of psychiatric symptoms including drug-related and severe physical illness, however, were excluded from this study. Patients who received other services than the psychiatric clinic in the same hospitals as the patients in the cases were treated as the control group. Additionally, controls had to be not diagnosed with major depressive disorder and other psychotic diseases when interviewed with Mini International Neuropsychiatric Interview (M.I.N.I.). Data were then analyzed by comparing the cases and control groups using University and Multivariate Analysis. Results: The data showed that personal stressful life events are in fact associated with major depressive disorder when analyzed with Unvaried Analysis, i.e. being unable to find a way out (OR=17.75, 95% CI=8.65-37.25), being unable to adjust to change (OR=12.20, 95% CI=12.20, 95% CI=4.86-32.50) being harassed (OR=9.88, 95% CI=2.81-41.43), being divorced/separated (OR=6.65, 95% CI=1.83-28.62). It was also shown that stressful life events occurred with the subject's social network were associated with major depressive disorder, i.e. departing from beloved person/husband/wife (OR=11.85, 95% CI+1.59-245.583), losing money in gambling (OR=3.89, 95% CI=1.20-14.01). Additionally, personal stressful life events which were strongly associated to increased major depressive disorder were inability to adjust to change (OR=16.83, 95% CI=4.29-66.01), and serious injury from accidents (OR=6.07, 95% CI=2.06-17.88). Conclusion: Those who experienced stressful life events, either personally or through their social network, were potentially at more risk of the onset of major depressive disorder. For that reason, it is important to prevent such circumstance by developing an effective depression screening and diagnostic test. More importantly, proper health education should be provided to people as well.

Keywords: stress, major depressive, depress, psychiatry

ปีที่เผยแพร่/Year: 2008

Address: Prasrimahabhodi Psychiatric Hospital, Department of Mental Health, Ministry of Public Health

Code: 200800338

ISSN/ISBN: 0125-6985

Country of publication: Thailand

Language: English

Category: Abstract

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