ผู้วิจัย/Authors: Sirichai Hongsanguansri, M.D. Suwannee Putthisri, M.D. Sombat Zartrungpak, M.D. Ronnachai Kongsakon, M.D., LL.B., M.Sc.

ชื่อเรื่อง/Title: Efficacy and Safety of Mirtazapine in Thai Patients with Major Depressive Disorder

แหล่งที่มา/Source: Journal of The Psychiatric Association of Thailand, Vol. 46 No.3 July-September 2000; P 179-786.

รายละเอียด / Details:

Objective To study the efficacy and tolerability of mirtazapine in Thai patients with moderate to severe major depressive disorder (MDD). Method This is a 6-week open study. Twenty-five patients with MDD (DSM-IV), 17-HAM-D score >18, were prescribed mirtazapine at flexible starting doses of 15 or 30 mg. Efficacy of mirtazapine was assessed by 17-HAM-D score, 17-HAM-D (anxiety/agitation factor), and 17-HAM-D (anxiety/somatization factor) at week 0, 2, and 6. Adverse drug effects were recorded. Results Baseline 17-HAM-D score of 27.0 + 6.7 significantly decreased to 13.0 + 4.9 (p ‹ 0.05) and 10.3 + 8.4 at week 2 and 6, respectively. Similar results were found for anxiety symptoms, both anxiety/agitation and anxiety/somatization. The most common adverse effect was somnolence (16%). Other adverse effects, including weakness, nausea, anxiety, and hair loss, were only mild degree of severity. One patient accidentally received mirtazapine during pregnancy without congenital malformation or perinatal complications. Conclusions Mirtazapine has good efficacy for patients with MDD, both depressive and associated anxiety symptoms, and is well tolerated. This is also a preliminary report that mirtazapine may be safe for use during pregnancy.

Keywords: mirtazapine, efficacy, safety, drug, antidepressant, depress, depression, major depressive disorder, pharmacology

ปีที่เผยแพร่/Year: 2001

Address: Department of Psychiatry, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama VI Road, Bangkok 10400, Thailand

Code: 0000031

ISSN/ISBN: 0125-6985

Country of publication: Thailand.

Language: English.

Category: Abstract Journal.

Download: -