ผู้วิจัย/Authors: Somrak Choovanichvong, M.D.

ชื่อเรื่อง/Title: Risperidone versus Haloperidol Treatment in First-Episode Schizophrenic Thai Patients

แหล่งที่มา/Source: Journal of The Psychiatric Association of Thailand, Vol. 45 No.2 April-June 2000 P 165-177.

รายละเอียด / Details:

Abstract Objective To evaluate the efficacy and safety of a atypical antipsychotic drug, risperidone, in comparison to a typical antipsychotic drug, haloperidol, in first-episode schizophrenic Thai patients. Method Single blind, prospective 24-week clinical study was performed on 22 patients from Srithunya Hospital. Patients were randomly assigned to the treatment with either 2-6 mg of risperidone (N=11) or 10-40 mg of haloperidol (N=11) daily. Outcome measurements and efficacy were assessed by the Positive and Negative Syndrome Scale (PANSS) and side effects especially extrapyramidal symptoms (EPS) were evaluated by the Extrapyramidal Symptom Rating Scale (ESRS). Results There were significant reduction in PANSS total scores, positive, negative, and general psychopathology scores in both groups when compared to the baseline (p‹0.05). However, there was no statistical difference between risperidone and haloperidol. In defining a responder as a patient with at least a 20% reduction in PANSS total scores from base line. Risperidone-treated group had higher response rate than haloperidol-treated group at the end of week8 (3.5? 1.8 mg/day; 81.8% versus 12.6? 10.3 mg/day; 54.5%, p=0.15). The depression subscale score in risperidone-treated group had much more decrease than in haloperidol-treated group. In considering the side effects during the 24-week follow-up periods, risperidone-treated patients experienced a higher incidence of drowsiness and tremor (p>0.05) whereas haloperidol-treated patients had a higher incidence of acute dystonia (p<0.05). Weight gain, a side effect limitation of both risperidone and haloperidol, may lead to loss of self-esteem in patients and result in noncompliance with the medication. Assessment of pulse rate, blood pressure, blood chemistry, complete blood count and physical examination revealed no clinically differences from baseline in both groups throughout the study. Conclusions The results suggest that risperidone was at least as effective as haloperidol in the treatment of first-episode schizophrenia and risperidone had more advantage in having less incidence of acute dystonia. However the number of the patients is too small to have the statistical power to show the differences in terms of efficacy. Thus further study in higher numbers of subject needs to be confirmed.

Keywords: first-episode, schizophrenia, schizophreniform disorder, risperidone, haloperidol, psychiatry, psychosis

ปีที่เผยแพร่/Year: 2000

Address: Psychiatric Unit, Srithanya Hospital, Nonthaburi 11000.

Code: 00000311

ISSN/ISBN: 0125-6985

Country of publication: Thailand.

Language: English.

Category: Abstract Journal.

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