ผู้วิจัย/Authors: Kanida Tassniyom, Suchat Paholpak, Sompon Tassniyom, Jiraporn Kiewyoo.

ชื่อเรื่อง/Title: Quetiapine for Primary Insomnia Patients: A Double-Blind, Randomized Controlled Trial.

แหล่งที่มา/Source: ASEAN Journal of Psychiatry. Vol. 9, Supplement 1, 26-29 August 2008, page 44.

รายละเอียด / Details:

Objective : To evaluate the efficacy of Quetiapine 25 mg in subjects with primary insomnia. Methods : Sixteen adults with DSM-IV-TR criteria for primary insomnia were randomized in a double-blind, placebo-controlled study. Patients were asked to record sleep diary one week prior to treatment. Then received 2 weeks of nightly treatment with either Quetiapine 25 mg or placebo. The main outcaomes were total sleep time (TST), sleep latency (SL), daytime alertness and functioning, and side effects. Results : 13 patients completed the study. Mean TST increased 124.92 minutes (SD 82.90) in Quetiapine group and 72.24 minutes (SD 45.52) in placebo group. Mean SL reduced 96.16 minute (SD 85.51) in Quetiapine group and 23.72 minute (SD 26.76) in placebo group. No statistical significant between both groups. In Quetiapine group, two patients reported side effects of morning drowsiness and dry lip and dry tongue. Conclusion : Quetiapine 25 mg seems to improve TST and reduce SL in primary insomnia with few side effects. However more sample size is needed to further support its efficacy.

Keywords: quetiapine, primary Insomnia patients, double-blind, randomized controlled trial

ปีที่เผยแพร่/Year: 2008

Address: Department of Psychiatry, Faculty of Medicine, Khon Kaen University, Thailand

Code: 2010000299

ISSN/ISBN: 0218-3420

Country of publication: Thailand

Language: English

Category: Abstract

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