ผู้วิจัย/Authors: Jay Cheol Kwon, Hong Chul Yeum, Suny-oung Ahn, Mihee Lee.

ชื่อเรื่อง/Title: 24 Weeks Open Labeled, Multi-center Observational Study for Efficacy on Cognitive Function of Donepezil in Binswanger Type Subcortical Vascular Dementia.

แหล่งที่มา/Source: ASEAN Journal of Psychiatry. Vol. 9, Supplement 1, 26-29 August 2008, page 55 - 56.

รายละเอียด / Details:

Objective: To evaluate the efficacy and tolerability of donepezil in patients with Binswanger type subcortical vascular dementia (B-sVD). Methods: Patients (n=34, mean age=71.8+7.12) with B-sVD from 8 multicentre, according to clinical and neuroradiological working criteria, were selected to receive donepezil 5mg/day (n=2) or donepezil 10mg/day (n=32, after 5mg/day) for 24 weeks. Our primary endpoints were change from baseline to weeks 12 and 24 in the Dementia version of Seoul Neuropsychological Screening Battery (SNSB-D) and Korean version Neuropsychiatric Inventory (K-NPI). Results: 24 patients receeived donepezil completed the study (mean age= 72.0 + 7.5 K-MMSE=21.0+5.1). After 12 weeks and 24 weeks, patients showed improvements in cognitive function on the SNSB-D compared baseline of 16.29 points at 12 weeks (p‹0.05) and 12.44 points at 24 weeks (p<0.05). Significant improvements were shown in only memory domain, immediate verbal recall and delayed recall tests. Subgroup with better cognitive funcction (SNSB-D>100) were more effective in frontal and memory domains than the other subgroup (SNSB-D<100). Withdrawal rates due to adverse events were very low (4.16%). Conclusion: Donepezil-treated patients demonstrated significant improvement in cognition compared with baseline, and donepezil was well tolerated.

Keywords: observation study, efficacy, cognitive function, donepezil, vascular dementia

ปีที่เผยแพร่/Year: 2008

Address: Department of Neurology, Changwon Fatima Hospital, Korea

Code: 2010000307

ISSN/ISBN: 0218-3420

Country of publication: Thailand

Language: English

Category: Abstract

Download: