ผู้วิจัย/Authors: Damrong Wae-Alee,M.D. Waran Tanchaiswad, M.D.

ชื่อเรื่อง/Title: Neuroleptic Malignant Syndrome : A review of 12 cases

แหล่งที่มา/Source: Journal of The Psychiatric Association of Thailand, Vol. 41 No.2 April-June 1996, P 89-109.

รายละเอียด / Details:

The patients with Neuroleptic Malignant Syndrome (NMS) admitted in Songklanagarind Hospital from December 1987 to April 1994 are reviewed. The cases consisted of 8 male and 4 female patients,aged 15-69 years (mean age = 37 years). Clinical manifestations of all cases were muscle rigidity, alterationof consciousness, hyperpyrexia (mean 39.2c) and autonomic nervous system disturbances. Laboratory findings were increased WBC over 10,000 cells/cu. mm in 10 cases, and increased creatinine phosphokinase (CPK) over 1000 U/L in 11 cases. Ten patients developed NMS after starting or changing the dosage of antipsychotic drugs and two after antidepressants. The symptoms occurred in 1-10 days after taking the medications (mean = 4.7 days) and lasted 4-36 days (mean = 18.8 days). Acute renal failure, pneumonia and urinary tract infection were found in 2,3 and 1 case(s) respectively. The patients were treated by immediate discontinuation of the medication and supportive measures. All cases recovered without any serious sequalae. Eight cases were suscessfully rechallenged with another antipsychotic drug without recurrence of NMS. This study suggests that starting or changing the dosage or type of medications might play some role in precipitating the occurrence of NMS, and the intensive supportive treatment should be carried out immediately to save the patients and to prevent morbidity.

Keywords: neuroleptic malignant syndrome, psychiatry, antipsychotic drug

ปีที่เผยแพร่/Year: 1996

Address: Department of Psychiatry, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla 90112

Code: 0000049

ISSN/ISBN: 0125-6985

Country of publication: Thailand.

Language: English.

Category: Abstract Journal.

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