ผู้วิจัย/Authors: Sarin Maskasame Thawatchai Krisanapra-kornkit, Jiraporn Khiewyoo.

ชื่อเรื่อง/Title: The Incidence of Clozapine Induced Leukopenia in Patients with Schizophrenia at Srinagarind Hospital.

แหล่งที่มา/Source: ASEAN Journal of Psychiatry. Vol. 9, Supplement 1, 26-29 August 2008, page 68.

รายละเอียด / Details:

Objective: Define the incidence of clozapine-induced leucopenia, neutropenia, and agranulocytosis in patients with schizophrenia at Srinagarind Hospital. Methods: A descriptive study was done by retrospective reviews of the medical records of schizophrenic outpatients at psychiatric clinic in Srinagarind Hospital who had received clozapine from January 1, 2003 to December 31, 2005. The demographic data, incidence rate, and incidence density of leucopenia, neutropenia, and agranulocytosis were collected. Results: One hundred and seventeen medical records were reviewed, 65 patients met the inclusion criteria. One patient developed neutropenia. The incidence rate of neutropenia was 1.5% and the incidence density of neutropenia was 0.01/year. No leukopenia or agranulocytosis was found in the present study. The complete blood counts were not obtained regularly due to the problems of patient’s adherence and variations in practice among the physicians. Conclusion: Neutropenia is uncommon. No leucopenia and agranulocytosis were found. According to variations of incidence reports among different studies, the monitoring of white blood count should be continued.

Keywords: incidence, clozapine, induced leukopenia, patients, schizophrenia

ปีที่เผยแพร่/Year: 2008

Address: Department of Psychiatry, Faculty of Medicine, Khon Kaen University, Thailand

Code: 2010000347

ISSN/ISBN: 0218-3420

Country of publication: Thailand

Language: English

Category: Abstract

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