ผู้วิจัย/Authors: Thawatchai Leelahanaj

ชื่อเรื่อง/Title: Aripiprazole Augmentation of Antidepressants for Treatment-resistant Major Depressive Disorder.

แหล่งที่มา/Source: Journal of the Psychiatric Association of Thailand, Vol. 53, No. 4, October-December, 2008, page 418.

รายละเอียด / Details:

Objective: To review the role of aripiprazole as augmentation of antidepressants in treatment-resistant major depressive disorder as well as its pharmacology, safety and tolerability. Method: A PubMed literature search of English papers was conducted using keywords major depressive disorder, treatment-resistant depression, atypical antipsychotics, aripiprazole and neurotransmitters. Data pertinent to the objective was reviewed and bibliographies of articles were further scrutinized for relevant literatures. Results: Aripiprazole is a partial agonist at 5-HT1a receptors and is an antagonist at 5-HT2a receptors that enhance dopamine release in prefrontal cortex and hippocampus. A dysfunction of mesocorticolimbic dopamine system may underlie the symptoms of major depressive disorder. Several open-label studies and two randomized, double-blind, placebo-controlled studies showed the efficacy of aripiprazole as augmentation of antidepressants in patients with treatment-resistant depression and partial response to antidepressants. In general, aripiprazole is well tolerated. Commonly reported adverse events were akathisia, agitation, nausea and headache. A starting dose of 2.5-5 mg/d, which enhanced tolerability compared with a starting dose of 10 mg/d, could be increased weekly in 5 mg/d increments to a maximum dose of 15-20 mg/d based on assessment of tolerability and clinical response. Conclusion: Adjunctive aripiprazole as a short-term augmentation atrategy to antidepressants is efficacious and well tolerated in patients with trweatment-resistant major depressive disorder and incomplete antidepressant response.

Keywords: aripiprazole, antidepressants, augmentation, treatment-resistant depression

ปีที่เผยแพร่/Year: 2008

Address: Department os Psychiatry and Neurology, Phramongkutklao Hospital, Bangkok

Code: 201000056

ISSN/ISBN: 0125-6985

Country of publication: Thailand

Language: English

Category: Abstract

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