ผู้วิจัย/Authors: Nipatt Karnchanathanalers, M.D.

ชื่อเรื่อง/Title: The Use of Risperidone in the Treatment of Schizophrenic Thai Patients

แหล่งที่มา/Source: Journal of The Psychiatric Association of Thailand, Vol. 43 No.2 April-June 1998; P 130-135.

รายละเอียด / Details:

Risperidone is a benzisoxazole derivative that has a relative high 5-HT2A /D2 ratio and relatively fewer and milder EPS than conventional neuroleptics at its clinically effective dose and extend its efficacy towards negative symptoms. An open study with risperidone treatment in 10 chronic schizophrenic Thai patients was conducted as 6 months prospective study to evaluate the efficacy and safety. Nine out of ten patients who completed the study, all of them showed the significant improvement in the Positive and Negative Syndrome Scale (PANSS) after treatment. The modal dose of risperidone was 4 mg/day. The patients experienced mild side effects such as sedation, tremors and akathisia. These preliminary results suggest that risperidone was effective for improving both positive and negative symptoms in chronic schizophrenia with acceptable side effects.

Keywords: risperidone, chronic schizophrenia, riperidal, drug, antipsychotic, psychiatry

ปีที่เผยแพร่/Year: 1998

Address: Department of Psychiatry, Chulalongkorn University, Bangkok10300, Thailand.

Code: 0000091

ISSN/ISBN: 0125-6985

Country of publication: Thailand.

Language: English.

Category: Abstract Journal.

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