ผู้วิจัย/Authors: Pichet Udomratn

ชื่อเรื่อง/Title: Incidence of Leukopenia and Agranulocytosis in 239 Thai patients treated with Clozapine

แหล่งที่มา/Source: Journal of The Psychiatric Association of Thailand, Vol. 45 No.3 July-September 2000, P 228-236

รายละเอียด / Details:

Objectives Clozapine was re-introduced again in Thailand on March 24, 1995 with WBC monitoring but there was no report concerning this issue. Therefore, the objectives of this study are: (1) to find out the incidence of clozapine induced neutropenia or agranulocytosis on Thai patients, (2) to compare results with other countries, and (3) to examine the currently monitoring system and propose a better national registry. Method WBC records of 239 Thai patients receiving clozapine between January 1, 1997 and September 30, 1998 were collected and analysed. The US definitions of mild, moderate, and severe leukopenia were used. Rates of leukopenia, agranulocytosis, and fatalities were reported in number and percentage. Results No neutropenia or agranulocytosis was found. Only 1.4% of clozapine treated patients at the 6-12 month period and 2.4% at the 12-18 month period had WBC in the range of 3500 - 4000/ mm3. Conclusions Although our data did not show the risk of developing clozapine induced leukopenia or agranulocytosis, it does not mean that we do not have such problems. The author recommends development of a centralized national registry for clozapine therapy to ensure safety of using clozapine nationwide and to serve as a tool for quality assurance. J Psychiatr Assoc Thailand 2000; 45(3): 229-236.

Keywords: clozapine, neutropenia, agranulocytosis, WBC monitoring, Thai patients

ปีที่เผยแพร่/Year: 2000

Address: Department of Psychiatry, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110.

Code: 0000156

ISSN/ISBN: 0125-6985

Country of publication: Thailand.

Language: English.

Category: Abstract Journal.

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