ผู้วิจัย/Authors: Prakob Pooviboonsuk, M.D., Ph.D.* Pimolvan Tappayuthpijarn, M.Sc. in Pharm* Taris Hincheeranund, M.S.T.*

ชื่อเรื่อง/Title: Hypnotic Effect of Modified Herbal Extract form Cassia siamea. in Human Subjects

แหล่งที่มา/Source: Journal of The Psychiatric Association of Thailand, Vol. 45 No.3 July-September 2000, P 253-260

รายละเอียด / Details:

Objective To evaluate the hypnotic effect and sleep quality of modified herbal extract from Cassia siamea in human subjects Method A 2-phase study of modified herbal extract from Cassia siamea leaves was performed on human subjects. The first phase was on alertness in normal volunteers by testing 2 preparation forms, tablet and syrup, while the second phase was on quality of sleep in short-term insomniac subjects which only the tablet form was tested. In the first phase of the study, a single-dose cross-over design with 7-day washout period was used to evaluate alertness in 20 healthy volunteer one hour after the drug. The tests used in this phase were event-related-potential (ERPs) tests and psychomotor performance tests which composed of card sorting, glass-bead picking, and reaction time tests. The evaluations for the second phase of the study were questionnaires which the subjects and his/her relatives living in the same house of the subjects were asked to complete on the day before and after taking drug. Results In the first phase, only in the experiment group receiving tablet form of the drug, showed that the N1P1 amplitude was reduced significantly (p = 0.027, 0.0001, 0.002) corresponded to hypnotic effect while only card sorting test was also significantly reduced. In the second phase, the drug also decreased sleep latency from 40-60 minutes to less than 30 minutes (p = 0.007), mid-sleep awakening from 2-3 times to 1 time (p = 0.055). The subjects were also satisfied with sleep quality which was much improved. Conclusions Overall results showed that the drug produced sleepiness in healthy subjects and also improved quality of sleep upon insomniac volunteers. It can be concluded that this modified herbal extract from Cassia siamea leaves could be used as a herbal hypnotic remedy for sleeplessness.

Keywords: hypnotic effect, sleep quality, Cassia siamea, hypnotic, sleep, hypnotic

ปีที่เผยแพร่/Year: 2000

Address: Department of Pharmacology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Code: 0000157

ISSN/ISBN: 0125-6985

Country of publication: Thailand.

Language: English.

Category: Abstract Journal.

Download: -