ผู้วิจัย/Authors: Chanpen Tangtrakul

ชื่อเรื่อง/Title: Retrospective study of the factor associalted with Agranulocytosis in clozapine recipients following Clozapine administration at Somdetchaopraya Hospital

แหล่งที่มา/Source: Journal of Mental Health of Thailand, Vol. 10, No 2, May 2002, Page 90.

รายละเอียด / Details:

Clozapine an atypical antipsychotic drug is onle 30-60% effective in patients resist to treatment with other antipsychotic. The most impottant adverse effect of this drug is agranulocytosis and death from infection. In this retrospective study, factors associated with agranulocytosis following clizapine administration at Somdetchapraya Hospital were estimate in 273 patient, records after administration of clozapine for 18 weeks the data of concentration of white blood cells neutrophil and blood platelets was collected and the granulocyte count were determined. Statistical analysis showed that percentage of the patients who had agranulocytosis, neutropenia leukopenia was 0.7,2.2, and 2.6 respectively. Sex, age at the beginning of clozapine administration, use of clozapine alone, use of clozapine with another drugs, uregularly of clozapine using and lack of following blood count did not associated with agranulocytosis. But the interesting point in this study was that, there were neutropenia and leukopenia 2.2% and 2.6% respectively, this may lead to agranulocytosis if the patients did not have a good warning on adverse effect. Although this study indicated that the incidence of agranulocytosis of patients at Somdetchaopraya Hospital was not striking ,further study should be made to gather more data to determine the association between risk factors and agranulocytosis. Such investigation has to be done completely and accordingly to the safety blood monitoring of this drug usage in order to reduce the agranulocytosis in these psychotic patients.

Keywords: clozapine, agranulocytosis, and clozapine safety monitoring program.

ปีที่เผยแพร่/Year: 2002

Address: Department of Mental Health Ministry of Public Health

Code: 0000280

ISSN/ISBN: 2859-497-X

Country of publication: Thailand.

Language: English.

Category: Abstract Journal.

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