ฐานข้อมูลวิจัยด้านสุขภาพจิตและจิตเวช

ผู้วิจัย/Authors: Mant Srisurapanont

ชื่อเรื่อง/Title: Alprazolam and Standard Antidepressants in the Treatment of Depression: A Meta-analysis of the Antidepressant Effect

แหล่งที่มา/Source: Journal of the Medical Association of Thailand, Vol. 80, No. 3, March 1997, Page 183-188.

รายละเอียด / Details:

Alprazolam differs form other benzodiazepines by the incorporation of a triazolo ring in the basic chemical structure . Several lines of evidence have supported that alprazolam and standard antidepressants have some similar actions, such as beta-adrenergic receptor down-regulation, antipanic effect, Because of the difference in opinions peratining to the antidepressant effect of alprazolam, this issue could not reach a firm conclusion. In the present analysis, we carried out a meta-analysis of 11 random controlled studied that compared the antidepressant effect of alprazolam and standard antidepressants in depressed patients. The results showed that the weighted mean effect size d (d) is equal to 0.06. In conclusion, the antidepressant effect of alprazolam is comparable to that of low dose tricyclic antidepressants. Very few studies have investigated severely depressed patients. Also, in long-term administration the lack of along term treatment study makes the isssue of alprazolam's benefits and disadvantages still undetermined.

Keywords: alprazolam, benzodiazepine, drug, antidepressant, depression, depress, treatment

ปีที่เผยแพร่/Year: 1997

Address: Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai

Code: 0000000094

ISSN/ISBN: 0125-2208

Country of publication: Thailand

Language: English.

Category: Summary of the Preceeding Article: Journal.

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