ผู้วิจัย/Authors: Oraphan P. Matangkasombut

ชื่อเรื่อง/Title: Bioavailability of two brands carbamazepine tablets

แหล่งที่มา/Source: Siriraj Hospital Gazette, Vol. 46, No 11, November 1994, Page 877-881

รายละเอียด / Details:

Bioavailability of carbamazepine (CBZ) tablet in thai subject has never been reported before. Owing to the big differrence of the drug cost and the National Drug policy to promote the use of generic drugs, it is therefire essential to compare the bioavailability of CBZ tablets available In thai market. Two brands of CBZ tablets that are commonly used in various hospitals were included in the present in 17 healthy thai volunteers. The drugs were given in randmized crossover fashion. Venous blood samples were drawn at 0, 1,2,3,4,6,8,10,24,48,72,96,120 and 144 hours prior to and after ingestion of 2X200 mg CBZ tablets. A washout period of 4 weeks was allowed because of its autoinduction of hepatic enzymes. Plasma samples were separated and the amount of CBZ contained in each samples were analysed by HPLC. The present results indicate a significantly slower rate of absorption of drug A but the extent of absorption appearsto be equal to that of drug B.

Keywords: carbamazepine, drug, bioavailability, anticonvulsant, CBZ

ปีที่เผยแพร่/Year: 1994

Address: Faculty of Medicine Siriraj Hospital, Mahidol University

Code: 00004133

ISSN/ISBN: 0125-152X

Country of publication: Thailand.

Language: English.

Category: Abstract Journal.

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